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Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts.
Santos, S; Voerman, E; Amiano, P; Barros, H; Beilin, L J; Bergström, A; Charles, M-A; Chatzi, L; Chevrier, C; Chrousos, G P; Corpeleijn, E; Costa, O; Costet, N; Crozier, S; Devereux, G; Doyon, M; Eggesbø, M; Fantini, M P; Farchi, S; Forastiere, F; Georgiu, V; Godfrey, K M; Gori, D; Grote, V; Hanke, W; Hertz-Picciotto, I; Heude, B; Hivert, M-F; Hryhorczuk, D; Huang, R-C; Inskip, H; Karvonen, A M; Kenny, L C; Koletzko, B; Küpers, L K; Lagström, H; Lehmann, I; Magnus, P; Majewska, R; Mäkelä, J; Manios, Y; McAuliffe, F M; McDonald, S W; Mehegan, J; Melén, E; Mommers, M; Morgen, C S; Moschonis, G; Murray, D; Ní Chaoimh, C.
Afiliação
  • Santos S; The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
  • Voerman E; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
  • Amiano P; The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
  • Barros H; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
  • Beilin LJ; Public Health Division of Gipuzkoa, San Sebastián, Spain.
  • Bergström A; BioDonostia Research Institute, San Sebastián, Spain.
  • Charles MA; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Chatzi L; EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
  • Chevrier C; Department of Public Health and Forensic Sciences and Medical Education, Unit of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal.
  • Chrousos GP; Medical School, Royal Perth Hospital Unit, The University of Western Australia, Perth, WA, Australia.
  • Corpeleijn E; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Costa O; Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
  • Costet N; INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), ORCHAD Team, Villejuif, France.
  • Crozier S; Paris Descartes University, Villejuif, France.
  • Devereux G; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Doyon M; Faculty of Medicine, Department of Social Medicine, University of Crete, Heraklion, Greece.
  • Eggesbø M; Department of Genetics and Cell Biology, Maastricht University, Maastricht, the Netherlands.
  • Fantini MP; Inserm UMR 1085, Irset - Research Institute for Environmental and Occupational Health, Rennes, France.
  • Farchi S; First Department of Pediatrics, Athens University Medical School, 'Aghia Sophia' Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Forastiere F; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Georgiu V; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
  • Godfrey KM; Inserm UMR 1085, Irset - Research Institute for Environmental and Occupational Health, Rennes, France.
  • Gori D; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
  • Grote V; Liverpool School of Tropical Medicine, Liverpool, UK.
  • Hanke W; Centre de Recherche du Centre Hospitalier de l'Universite de Sherbrooke, Sherbrooke, QC, Canada.
  • Hertz-Picciotto I; Department of Exposure and Environmental Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
  • Heude B; The Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Hivert MF; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
  • Hryhorczuk D; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
  • Huang RC; Faculty of Medicine, Department of Social Medicine, University of Crete, Heraklion, Greece.
  • Inskip H; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
  • Karvonen AM; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Kenny LC; The Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Koletzko B; Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilian-Universität Munich, Munich, Germany.
  • Küpers LK; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
  • Lagström H; Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA, USA.
  • Lehmann I; INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), ORCHAD Team, Villejuif, France.
  • Magnus P; Paris Descartes University, Villejuif, France.
  • Majewska R; Centre de Recherche du Centre Hospitalier de l'Universite de Sherbrooke, Sherbrooke, QC, Canada.
  • Mäkelä J; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • Manios Y; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
  • McAuliffe FM; Center for Global Health, University of Illinois College of Medicine, Chicago, IL, USA.
  • McDonald SW; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia.
  • Mehegan J; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
  • Melén E; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Mommers M; Department of Health Security, National Institute for Health and Welfare, Kuopio, Finland.
  • Morgen CS; Irish Centre for Fetal and Neonatal Translational Research, Cork University Maternity Hospital, University College Cork, Cork, Ireland.
  • Moschonis G; Department of Obstetrics and Gynaecology, Cork University Maternity Hospital, Cork, Ireland.
  • Murray D; Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilian-Universität Munich, Munich, Germany.
  • Ní Chaoimh C; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
BJOG ; 126(8): 984-995, 2019 Jul.
Article em En | MEDLINE | ID: mdl-30786138
OBJECTIVE: To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. DESIGN: Individual participant data meta-analysis of 39 cohorts. SETTING: Europe, North America, and Oceania. POPULATION: 265 270 births. METHODS: Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. MAIN OUTCOME MEASURES: Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. RESULTS: Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. CONCLUSIONS: Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. TWEETABLE ABSTRACT: Promoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Female / Humans / Newborn / Pregnancy País/Região como assunto: America do norte / Europa / Oceania Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Female / Humans / Newborn / Pregnancy País/Região como assunto: America do norte / Europa / Oceania Idioma: En Ano de publicação: 2019 Tipo de documento: Article