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Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.
Daya, Michelle; Rafaels, Nicholas; Brunetti, Tonya M; Chavan, Sameer; Levin, Albert M; Shetty, Aniket; Gignoux, Christopher R; Boorgula, Meher Preethi; Wojcik, Genevieve; Campbell, Monica; Vergara, Candelaria; Torgerson, Dara G; Ortega, Victor E; Doumatey, Ayo; Johnston, Henry Richard; Acevedo, Nathalie; Araujo, Maria Ilma; Avila, Pedro C; Belbin, Gillian; Bleecker, Eugene; Bustamante, Carlos; Caraballo, Luis; Cruz, Alvaro; Dunston, Georgia M; Eng, Celeste; Faruque, Mezbah U; Ferguson, Trevor S; Figueiredo, Camila; Ford, Jean G; Gan, Weiniu; Gourraud, Pierre-Antoine; Hansel, Nadia N; Hernandez, Ryan D; Herrera-Paz, Edwin Francisco; Jiménez, Silvia; Kenny, Eimear E; Knight-Madden, Jennifer; Kumar, Rajesh; Lange, Leslie A; Lange, Ethan M; Lizee, Antoine; Maul, Pissamai; Maul, Trevor; Mayorga, Alvaro; Meyers, Deborah; Nicolae, Dan L; O'Connor, Timothy D; Oliveira, Ricardo Riccio; Olopade, Christopher O; Olopade, Olufunmilayo.
Afiliação
  • Daya M; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Rafaels N; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Brunetti TM; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Chavan S; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Levin AM; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, 48202, USA.
  • Shetty A; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Gignoux CR; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Boorgula MP; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Wojcik G; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Campbell M; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Vergara C; Department of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA.
  • Torgerson DG; Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
  • Ortega VE; Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, 27157, USA.
  • Doumatey A; Center for Research on Genomics & Global Health, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Johnston HR; Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA.
  • Acevedo N; Institute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia.
  • Araujo MI; Immunology Service, Universidade Federal da Bahia, Salvador, 401110170, Brazil.
  • Avila PC; Department of Medicine, Northwestern University, Chicago, IL, 60611, USA.
  • Belbin G; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Bleecker E; Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
  • Bustamante C; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Caraballo L; Institute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia.
  • Cruz A; Universidade Federal da Bahia, Salvador, 401110170, Brazil.
  • Dunston GM; Department of Microbiology, Howard University College of Medicine, Washington, DC, 20059, USA.
  • Eng C; Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
  • Faruque MU; National Human Genome Center, Howard University College of Medicine, Washington, DC, 20059, USA.
  • Ferguson TS; Caribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica.
  • Figueiredo C; Departamento de Biorregulacao, Universidade Federal da Bahia, Salvador, 401110170, Brazil.
  • Ford JG; Department of Medicine, Einstein Medical Center, Philadelphia, PA, 19141, USA.
  • Gan W; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Gourraud PA; Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France.
  • Hansel NN; Department of Medicine, Johns Hopkins University, Baltimore, MD, 21224, USA.
  • Hernandez RD; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, 94143, USA.
  • Herrera-Paz EF; Facultad de Medicina, Universidad Católica de Honduras, San Pedro Sula, 21102, Honduras.
  • Jiménez S; Universidad Tecnológica Centroamericana (UNITEC), Facultad de Ciencias Médicas, Tegucigalpa, Honduras.
  • Kenny EE; Institute for Immunological Research, Universidad de Cartagena, Cartagena, 130000, Colombia.
  • Knight-Madden J; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Kumar R; Caribbean Institute for Health Research, The University of the West Indies, Kingston, 00007, Jamaica.
  • Lange LA; Department of Pediatrics, Northwestern University, Chicago, IL, 60611, USA.
  • Lange EM; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Lizee A; Department of Medicine, University of Colorado Denver, Aurora, CO, 80045, USA.
  • Maul P; Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR, 1064, ATIP-Avenir, Equipe 5, Nantes, France.
  • Maul T; Genetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre, Jemmots Lane, St. Michael, BB11115, Barbados.
  • Mayorga A; Genetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre, Jemmots Lane, St. Michael, BB11115, Barbados.
  • Meyers D; Centro de Neumologia y Alergias, San Pedro Sula, 21102, Honduras.
  • Nicolae DL; Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA.
  • O'Connor TD; Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.
  • Oliveira RR; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
  • Olopade CO; Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Salvador, 40296-710, Brazil.
  • Olopade O; Department of Medicine and Center for Global Health, University of Chicago, Chicago, IL, 60637, USA.
Nat Commun ; 10(1): 880, 2019 02 20.
Article em En | MEDLINE | ID: mdl-30787307
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies / Systematic_reviews Limite: Humans País/Região como assunto: America do norte Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies / Systematic_reviews Limite: Humans País/Região como assunto: America do norte Idioma: En Ano de publicação: 2019 Tipo de documento: Article