Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile.

Mamareli, Panagiota; Kruse, Friederike; Friedrich, Christin; Smit, Nathiana; Strowig, Till; Sparwasser, Tim; Lochner, Matthias

Mamareli, Panagiota; Kruse, Friederike; Friedrich, Christin; Smit, Nathiana; Strowig, Till; Sparwasser, Tim; Lochner, Matthias.

Afiliação

Mamareli P; Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Kruse F; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University Mainz, Germany.
Friedrich C; Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Smit N; Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.
Strowig T; Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.
Sparwasser T; Institute of Systems Immunology, University of Würzburg, Würzburg, Germany.
Lochner M; Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.

Eur J Immunol ; 49(5): 747-757, 2019 05.

Article em En | MEDLINE | ID: mdl-30802297

Assuntos

Clostridioides difficile/imunologia; Enterocolite Pseudomembranosa/imunologia; Enterocolite Pseudomembranosa/metabolismo; Mucosa Intestinal/imunologia; Mucosa Intestinal/metabolismo; Fator 88 de Diferenciação Mieloide/metabolismo; Transdução de Sinais; Animais; Células Dendríticas/imunologia; Células Dendríticas/metabolismo; Modelos Animais de Doenças; Enterocolite Pseudomembranosa/microbiologia; Interações Hospedeiro-Patógeno/genética; Interações Hospedeiro-Patógeno/imunologia; Mucosa Intestinal/patologia; Macrófagos/imunologia; Macrófagos/metabolismo; Camundongos

Palavras-chave

C. difficile infection; Dendritic cells; Intestinal epithelium; Macrophages; Myd88

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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