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PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding.
Tinworth, Christopher P; Lithgow, Hannah; Dittus, Lars; Bassi, Zuni I; Hughes, Sophie E; Muelbaier, Marcel; Dai, Han; Smith, Ian E D; Kerr, William J; Burley, Glenn A; Bantscheff, Marcus; Harling, John D.
Afiliação
  • Tinworth CP; GSK Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Lithgow H; Department of Pure and Applied Chemistry, WestCHEM , University of Strathclyde , 295 Cathedral Street , Glasgow G1 1XL , U.K.
  • Dittus L; GSK Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Bassi ZI; Department of Pure and Applied Chemistry, WestCHEM , University of Strathclyde , 295 Cathedral Street , Glasgow G1 1XL , U.K.
  • Hughes SE; Cellzome GmbH, GlaxoSmithKline , Meyerhofstrasse 1 , D-69117 Heidelberg , Germany.
  • Muelbaier M; GSK Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Dai H; GSK Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Smith IED; Cellzome GmbH, GlaxoSmithKline , Meyerhofstrasse 1 , D-69117 Heidelberg , Germany.
  • Kerr WJ; GlaxoSmithKline , 1250 South Collegeville Road , Collegeville , Pennsylvania 19426 , United States.
  • Burley GA; GSK Medicines Research Centre , Gunnels Wood Road , Stevenage SG1 2NY , U.K.
  • Bantscheff M; Department of Pure and Applied Chemistry, WestCHEM , University of Strathclyde , 295 Cathedral Street , Glasgow G1 1XL , U.K.
  • Harling JD; Department of Pure and Applied Chemistry, WestCHEM , University of Strathclyde , 295 Cathedral Street , Glasgow G1 1XL , U.K.
ACS Chem Biol ; 14(3): 342-347, 2019 03 15.
Article em En | MEDLINE | ID: mdl-30807093

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article