Discovery of a small molecule RXFP3/4 agonist that increases food intake in rats upon acute central administration.

DeChristopher, Brian; Park, Soo-Hee; Vong, Linh; Bamford, Derek; Cho, Hyun-Hee; Duvadie, Rohit; Fedolak, Allison; Hogan, Christopher; Honda, Toshiyuki; Pandey, Pramod; Rozhitskaya, Olga; Su, Liansheng; Tomlinson, Elizabeth; Wallace, Iain

DeChristopher, Brian; Park, Soo-Hee; Vong, Linh; Bamford, Derek; Cho, Hyun-Hee; Duvadie, Rohit; Fedolak, Allison; Hogan, Christopher; Honda, Toshiyuki; Pandey, Pramod; Rozhitskaya, Olga; Su, Liansheng; Tomlinson, Elizabeth; Wallace, Iain.

Afiliação

DeChristopher B; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States. Electronic address: badechri@gmail.com.
Park SH; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Vong L; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Bamford D; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Cho HH; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Duvadie R; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Fedolak A; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Hogan C; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Honda T; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Pandey P; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Rozhitskaya O; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Su L; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Tomlinson E; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.
Wallace I; Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States.

Bioorg Med Chem Lett ; 29(8): 991-994, 2019 04 15.

Article em En | MEDLINE | ID: mdl-30824200

Assuntos

Ingestão de Alimentos/efeitos dos fármacos; Receptores Acoplados a Proteínas G/agonistas; Bibliotecas de Moléculas Pequenas/química; Animais; Células CHO; Cricetinae; Cricetulus; AMP Cíclico/metabolismo; Descoberta de Drogas; Ligantes; Peptídeos/química; Peptídeos/farmacologia; Ratos; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Receptores de Peptídeos/agonistas; Receptores de Peptídeos/genética; Receptores de Peptídeos/metabolismo; Relaxina/farmacologia; Bibliotecas de Moléculas Pequenas/farmacologia

Palavras-chave

Insulin-like peptide; RXFP3; RXFP4; Relaxin-3

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article