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Three-dimensional ultrashort echo time imaging with tricomponent analysis for human cortical bone.
Lu, Xing; Jerban, Saeed; Wan, Lidi; Ma, Yajun; Jang, Hyungseok; Le, Nicole; Yang, Wenhui; Chang, Eric Y; Du, Jiang.
Afiliação
  • Lu X; Department of Radiology, University of California San Diego, San Diego, California.
  • Jerban S; Institute of Electrical Engineering, Chinese Academy of Science, Beijing, China.
  • Wan L; Department of Radiology, University of California San Diego, San Diego, California.
  • Ma Y; Department of Radiology, University of California San Diego, San Diego, California.
  • Jang H; Department of Radiology, University of California San Diego, San Diego, California.
  • Le N; Department of Radiology, University of California San Diego, San Diego, California.
  • Yang W; Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, California.
  • Chang EY; Institute of Electrical Engineering, Chinese Academy of Science, Beijing, China.
  • Du J; Department of Radiology, University of California San Diego, San Diego, California.
Magn Reson Med ; 82(1): 348-355, 2019 07.
Article em En | MEDLINE | ID: mdl-30847989
PURPOSE: To investigate tricomponent analysis of human cortical bone using a multipeak fat signal model with 3D ultrashort TE Cones sequences on a clinical 3T scanner. METHODS: Tricomponent fitting of bound water, pore water, and fat content using a multipeak fat spectra model was proposed for 3D ultrashort TE imaging of cortical bone. Three-dimensional ultrashort TE Cones acquisitions combined with tricomponent analysis were used to investigate bound and pore water T2∗ and fractions, as well as fat T2∗ and fraction in cortical bone. Feasibility studies were performed on 9 human cortical bone specimens with regions of interest selected from the endosteum to the periosteum in 4 circumferential regions. Microcomputed tomography studies were performed to measure bone porosity and bone mineral density for comparison and validation of the bound and pore water analyses. RESULTS: The oscillation of the signal decay was well-fitted with the proposed tricomponent model. The sum of the pore water and fat fractions from tricomponent analysis showed a high correlation with microcomputed tomography porosity (R = 0.74, P < 0.01). Estimated bound-water fraction also demonstrated a high correlation with bone mineral density (R = 0.70, P < 0.01). CONCLUSION: Tricomponent analysis significantly improves the estimation of bound-water and pore-water fractions in human cortical bone.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article