Three-dimensional ultrashort echo time imaging with tricomponent analysis for human cortical bone.
Magn Reson Med
; 82(1): 348-355, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30847989
PURPOSE: To investigate tricomponent analysis of human cortical bone using a multipeak fat signal model with 3D ultrashort TE Cones sequences on a clinical 3T scanner. METHODS: Tricomponent fitting of bound water, pore water, and fat content using a multipeak fat spectra model was proposed for 3D ultrashort TE imaging of cortical bone. Three-dimensional ultrashort TE Cones acquisitions combined with tricomponent analysis were used to investigate bound and pore water T2∗ and fractions, as well as fat T2∗ and fraction in cortical bone. Feasibility studies were performed on 9 human cortical bone specimens with regions of interest selected from the endosteum to the periosteum in 4 circumferential regions. Microcomputed tomography studies were performed to measure bone porosity and bone mineral density for comparison and validation of the bound and pore water analyses. RESULTS: The oscillation of the signal decay was well-fitted with the proposed tricomponent model. The sum of the pore water and fat fractions from tricomponent analysis showed a high correlation with microcomputed tomography porosity (R = 0.74, P < 0.01). Estimated bound-water fraction also demonstrated a high correlation with bone mineral density (R = 0.70, P < 0.01). CONCLUSION: Tricomponent analysis significantly improves the estimation of bound-water and pore-water fractions in human cortical bone.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article