METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1/STAT5/C/EBPß pathway <i>via</i> an m<sup>6</sup>A-YTHDF2-dependent manner.

Yao, Yongxi; Bi, Zhen; Wu, Ruifan; Zhao, Yuanling; Liu, Youhua; Liu, Qing; Wang, Yizhen; Wang, Xinxia

METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1/STAT5/C/EBPß pathway via an m⁶A-YTHDF2-dependent manner.

Yao, Yongxi; Bi, Zhen; Wu, Ruifan; Zhao, Yuanling; Liu, Youhua; Liu, Qing; Wang, Yizhen; Wang, Xinxia.

Afiliação

Yao Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Bi Z; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Wu R; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Zhao Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Liu Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Liu Q; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Wang Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Wang X; Key Laboratory of Animal Nutrition and Feed Sciences in Eastern China, Ministry of Agriculture, Hangzhou, China.

FASEB J ; 33(6): 7529-7544, 2019 06.

Article em En | MEDLINE | ID: mdl-30865855

Assuntos

Proteína beta Intensificadora de Ligação a CCAAT/metabolismo; Diferenciação Celular/fisiologia; Janus Quinase 1/metabolismo; Células-Tronco Mesenquimais/química; Metiltransferases/fisiologia; Fator de Transcrição STAT5/metabolismo; Adipogenia/fisiologia; Animais; Proteína beta Intensificadora de Ligação a CCAAT/genética; Humanos; Metiltransferases/genética; Suínos; Transcrição Gênica

Palavras-chave

adipogenesis; mA methylation; porcine model; stem cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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