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Evaluation of MEDAG gene expression in papillary thyroid microcarcinoma: associations with histological features, regional lymph node metastasis and prognosis.
Song, Yang; Fu, Li-Jun; Li, Hong-Ting; Qiu, Xin-Guang.
Afiliação
  • Song Y; Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Construction of Road No. 1, Zhengzhou, P. R. China.
  • Fu LJ; Department of Oncological Surgery, Xinyang Cental Hospital, Siyi of Road No. 1, Xinyang, P. R. China.
  • Li HT; Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Construction of Road No. 1, Zhengzhou, P. R. China.
  • Qiu XG; Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Construction of Road No. 1, Zhengzhou, P. R. China.
Sci Rep ; 9(1): 5800, 2019 04 09.
Article em En | MEDLINE | ID: mdl-30967566
ABSTRACT
Papillary thyroid microcarcinoma accounts for a large proportion of papillary thyroid carcinoma, especially among new cases. Many  PTMC patients have regional lymph node metastasis, with some experiencing recurrence and even death. However, the risk factors and mechanism by which PTMC relates to these factors are unknown. In this study, differentially expressed genes were identified with microarray from The Cancer Genome Atlas, followed by analysis using the Kyoto Encyclopedia of Genes and Genomes. Immunohistochemistry, immunofluorescence, western blot and Oil Red O staining were carried out to evaluate expression levels and functional alterations. Mesenteric Estrogen Dependent Adipogenesis expression was observed in almost all cases of papillary thyroid microcarcinomas, and the location of expression was associated with histological subtype. High expression was correlated with metastasis and poor disease-free survival. Furthermore, the enrichment analysis indicated that Mesenteric Estrogen Dependent Adipogenesis expression may be associated with metabolic reprogramming to influence metastasis and prognosis. These findings contribute to a better understanding of how Mesenteric Estrogen Dependent Adipogenesis affects metastasis and the prognosis of papillary thyroid microcarcinoma patients and suggest that Mesenteric Estrogen Dependent Adipogenesis expression may be a novel prognostic marker in these patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article