Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR.

Setz, Corinna S; Khadour, Ahmad; Renna, Valerio; Iype, Joseena; Gentner, Eva; He, Xiaocui; Datta, Moumita; Young, Marc; Nitschke, Lars; Wienands, Jürgen; Maity, Palash C; Reth, Michael; Jumaa, Hassan

Setz, Corinna S; Khadour, Ahmad; Renna, Valerio; Iype, Joseena; Gentner, Eva; He, Xiaocui; Datta, Moumita; Young, Marc; Nitschke, Lars; Wienands, Jürgen; Maity, Palash C; Reth, Michael; Jumaa, Hassan.

Afiliação

Setz CS; Institute of Immunology, Ulm University Medical Center, Ulm, Germany.
Khadour A; Institute of Immunology, Ulm University Medical Center, Ulm, Germany.
Renna V; Institute of Immunology, Ulm University Medical Center, Ulm, Germany.
Iype J; Institute of Immunology, Ulm University Medical Center, Ulm, Germany.
Gentner E; Department of Molecular Immunology, Biology III, Faculty of Biology, Albert-Ludwigs University of Freiburg, Freiburg, Germany.
He X; Institute of Immunology, Ulm University Medical Center, Ulm, Germany.
Datta M; Department of Molecular Immunology, Biology III, Faculty of Biology, Albert-Ludwigs University of Freiburg, Freiburg, Germany.
Young M; Institute of Immunology, Ulm University Medical Center, Ulm, Germany.
Nitschke L; Institute of Immunology, Ulm University Medical Center, Ulm, Germany.
Wienands J; Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Maity PC; Cellular and Molecular Immunology, Georg August University Göttingen, Göttingen, Germany.
Reth M; Institute of Immunology, Ulm University Medical Center, Ulm, Germany.
Jumaa H; Department of Molecular Immunology, Biology III, Faculty of Biology, Albert-Ludwigs University of Freiburg, Freiburg, Germany.

EMBO J ; 38(11)2019 06 03.

Article em En | MEDLINE | ID: mdl-31015337

Assuntos

Linfócitos B/fisiologia; Centro Germinativo/fisiologia; Imunoglobulina D/genética; PTEN Fosfo-Hidrolase/fisiologia; Receptores de Antígenos de Linfócitos B/genética; Animais; Células Cultivadas; Proteína Forkhead Box O1/fisiologia; Regulação da Expressão Gênica/imunologia; Centro Germinativo/metabolismo; Imunoglobulina D/imunologia; Imunoglobulina D/metabolismo; Camundongos; Camundongos Transgênicos; PTEN Fosfo-Hidrolase/genética; Receptores de Antígenos de Linfócitos B/metabolismo; Transdução de Sinais/genética; Transdução de Sinais/imunologia

Palavras-chave

Bcell differentiation; FoxO1; Pten; immune response; tolerance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article