A Fused Hexacyclic Ring System: Diastereoselective Polycyclization of 2,4-Dienals through an Interrupted iso-Nazarov Reaction.
Angew Chem Int Ed Engl
; 58(29): 9969-9973, 2019 07 15.
Article
em En
| MEDLINE
| ID: mdl-31090996
ABSTRACT
We report an unprecedented domino polycyclization from readily available 2,4-dienals and cyclic α,ß-unsaturated imines that is initiated by an iso-Nazarov reaction. This Brønsted acid promoted reaction enables the concomitant formation of four bonds, three cycles, and four contiguous stereogenic centers to yield elaborated structures in a single operation. A range of fused hexacyclic molecules is obtained in a highly diastereoselective manner.
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Coleções:
01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article