Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy.

Lala-Tabbert, Neena; Lejmi-Mrad, Rim; Timusk, Kristen; Fukano, Marina; Holbrook, Janelle; St-Jean, Martine; LaCasse, Eric C; Korneluk, Robert G

Lala-Tabbert, Neena; Lejmi-Mrad, Rim; Timusk, Kristen; Fukano, Marina; Holbrook, Janelle; St-Jean, Martine; LaCasse, Eric C; Korneluk, Robert G.

Afiliação

Lala-Tabbert N; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.
Lejmi-Mrad R; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Timusk K; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.
Fukano M; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Holbrook J; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.
St-Jean M; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
LaCasse EC; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.
Korneluk RG; Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.

Skelet Muscle ; 9(1): 13, 2019 05 24.

Article em En | MEDLINE | ID: mdl-31126323

Assuntos

Proteínas Inibidoras de Apoptose/antagonistas & inibidores; Denervação Muscular/efeitos adversos; Atrofia Muscular/etiologia; Animais; Proteínas Reguladoras de Apoptose/farmacologia; Linhagem Celular; Feminino; Marcação de Genes; Humanos; Proteínas Inibidoras de Apoptose/deficiência; Proteínas Inibidoras de Apoptose/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteínas Mitocondriais/farmacologia; Atrofia Muscular/metabolismo; Atrofia Muscular/patologia; Mioblastos Esqueléticos/metabolismo; NF-kappa B/metabolismo; Transdução de Sinais; Tiazóis/farmacologia; Regulação para Cima

Palavras-chave

Atrogin-1; Denervation; MuRF1; Muscle atrophy; NF-κB; cIAP1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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