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Positive pharmacokinetic effect of azathioprine co-medication on infliximab trough levels is dose-dependent.
Polakovicova, Veronika; Kadleckova, Barbora; Lucenicova, Jana; Otottova, Katarina; Kinova, Sona; Mikus, Peter; Zelinkova, Zuzana.
Afiliação
  • Polakovicova V; Gastrocentrum Bajkalská, Bratislava, Slovakia; 1st Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
  • Kadleckova B; IBD Center, Bratislava, Slovakia.
  • Lucenicova J; Laboratory of Hematology and Biochemistry, St Michael's Hospital, Bratislava, Slovakia.
  • Otottova K; IBD Center, Bratislava, Slovakia.
  • Kinova S; 1st Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
  • Mikus P; Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
  • Zelinkova Z; Department of Gastroenterology and Gastrointestinal Endoscopy, St Michael's Hospital, Bratislava, Slovakia. Electronic address: zuzana.zelinkova@nsmas.sk.
Dig Liver Dis ; 51(8): 1112-1116, 2019 08.
Article em En | MEDLINE | ID: mdl-31147215
BACKGROUND: Thiopurines seem to have positive effect on the pharmacokinetics of anti-tumor necrosis factor biologics. It has been suggested that a reduced dose of thiopurines is sufficient to achieve this synergism. AIMS: To assess the differences of infliximab (IFX) trough levels according to the dose of concomitantly used azathioprine (AZA). PATIENTS & METHODS: All IBD patients treated with IFX (Remicade®) in two IBD centres between November 2015 and April 2017 were eligible. Infliximab trough levels were assessed by ELISA (Ridascreen®, R-Biopharm). The differences in IFX trough levels according to AZA dose were analyzed statistically. RESULTS: In total, 125 patients were included, 42 pts (33.6%) on infliximab monotherapy, 83 pts (66.4%) using combined immune suppression. The respective median IFX levels according to AZA dose were as follows: group 1 (no concomitant AZA) 2.83 µg/ml (range 0-12); group 2 (AZA dose less than 1 mg/kg) 4.91 µg/ml (range 0.09-15.36); group 3 (AZA dose 1 < 2 mg/kg) 5.67 (range 0.16-16.97); group 4 (AZA dose above 2 mg/kg) 7.53 µg/ml (range 1.15-8.73). The differences in IFX trough levels between the respective groups according to AZA dose were statistically significant (p = 0.0159). CONCLUSION: The positive effect of azathioprine on infliximab levels seems to be dependent on the dose of concomitantly used azathioprine.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article