Angiopoietin-like 2 upregulation promotes human chondrocyte injury via NF-&#954;B and p38/MAPK signaling pathway.

Shan, Wenshan; Cheng, Chao; Huang, Wei; Ding, Zhenfei; Luo, Sha; Cui, Guanjun; Lu, Wei; Liu, Fuen; Xu, JieGou; He, Wei; Yin, Zongsheng

Angiopoietin-like 2 upregulation promotes human chondrocyte injury via NF-κB and p38/MAPK signaling pathway.

Shan, Wenshan; Cheng, Chao; Huang, Wei; Ding, Zhenfei; Luo, Sha; Cui, Guanjun; Lu, Wei; Liu, Fuen; Xu, JieGou; He, Wei; Yin, Zongsheng.

Afiliação

Shan W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Cheng C; Department of Orthopaedics, The Fourth Affiliated Hospital of Anhui Medical University, 372#Tun Xi Road, Hefei, 230032, Anhui, China.
Huang W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Ding Z; Division of Life Sciences and Medicine, Department of Orthopaedics, The First Affiliated Hospital of USTC, University of Science and Technology of China, 17#Lu Jiang Road, Hefei, 230001, Anhui, China.
Luo S; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Cui G; School of Basic Medical Science, and the First Clinical Medical College, Anhui Medical University, 81# Mei Shan Road, Hefei, 230032, Anhui, China.
Lu W; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Liu F; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
Xu J; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, 218#Ji Xi Road, Hefei, 230032, Anhui, China.
He W; School of Basic Medical Science, and the First Clinical Medical College, Anhui Medical University, 81# Mei Shan Road, Hefei, 230032, Anhui, China. xujiegou@ahmu.edu.cn.
Yin Z; School of Basic Medical Science, and the First Clinical Medical College, Anhui Medical University, 81# Mei Shan Road, Hefei, 230032, Anhui, China. weihe@ahmu.edu.cn.

J Bone Miner Metab ; 37(6): 976-986, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31214838

Assuntos

Proteínas Semelhantes a Angiopoietina/genética; Condrócitos/metabolismo; Condrócitos/patologia; Interleucina-1beta/farmacologia; Sistema de Sinalização das MAP Quinases; NF-kappa B/metabolismo; Regulação para Cima/genética; Proteína 2 Semelhante a Angiopoietina; Proteínas Semelhantes a Angiopoietina/metabolismo; Cartilagem/efeitos dos fármacos; Cartilagem/metabolismo; Cartilagem/patologia; Células Cultivadas; Condrócitos/efeitos dos fármacos; Colágeno Tipo II/metabolismo; Humanos; Integrina alfa5beta1/metabolismo; Interleucina-6/biossíntese; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Metaloproteinases da Matriz/metabolismo; Osteoartrite/metabolismo; Osteoartrite/patologia; Regulação para Cima/efeitos dos fármacos

Palavras-chave

ANGPTL2; ECM degradation; Inflammation mediators production; Osteoarthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article