Hypoxic ER stress suppresses ß-catenin expression and promotes cooperation between the transcription factors XBP1 and HIF1&#945; for cell survival.

Xia, Zhixiong; Wu, Shiyong; Wei, Xin; Liao, Yifei; Yi, Ping; Liu, Yong; Liu, Jianmiao; Liu, Jianfeng

Hypoxic ER stress suppresses ß-catenin expression and promotes cooperation between the transcription factors XBP1 and HIF1α for cell survival.

Xia, Zhixiong; Wu, Shiyong; Wei, Xin; Liao, Yifei; Yi, Ping; Liu, Yong; Liu, Jianmiao; Liu, Jianfeng.

Afiliação

Xia Z; Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Wu S; Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Wei X; Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Liao Y; Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Yi P; Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
Liu Y; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Institute for Advanced Studies, Wuhan University, Wuhan 430072, China.
Liu J; Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China jmliu@mail.hust.edu.cn.
Liu J; Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China jfliu@mail.hust.edu.cn.

J Biol Chem ; 294(37): 13811-13821, 2019 09 13.

Article em En | MEDLINE | ID: mdl-31350332

Assuntos

Estresse do Retículo Endoplasmático/fisiologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Proteína 1 de Ligação a X-Box/metabolismo; Animais; Apoptose/fisiologia; Linhagem Celular; Sobrevivência Celular/fisiologia; Retículo Endoplasmático/metabolismo; Regulação da Expressão Gênica/genética; Células HEK293; Humanos; Hipóxia/genética; Hipóxia/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Camundongos; Fatores de Transcrição/metabolismo; Resposta a Proteínas não Dobradas; Via de Sinalização Wnt; Proteína 1 de Ligação a X-Box/genética; beta Catenina/genética; beta Catenina/metabolismo

Palavras-chave

Wnt signaling; X-boxbinding protein 1 (XBP1); cancer biology; endoplasmic reticulum stress (ER stress); hypoxia-inducible factor (HIF)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article