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Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.
Amezcua Vesely, Maria Carolina; Pallis, Paris; Bielecki, Piotr; Low, Jun Siong; Zhao, Jun; Harman, Christian C D; Kroehling, Lina; Jackson, Ruaidhrí; Bailis, Will; Licona-Limón, Paula; Xu, Hao; Iijima, Norifumi; Pillai, Padmini S; Kaplan, Daniel H; Weaver, Casey T; Kluger, Yuval; Kowalczyk, Monika S; Iwasaki, Akiko; Pereira, Joao P; Esplugues, Enric; Gagliani, Nicola; Flavell, Richard A.
Afiliação
  • Amezcua Vesely MC; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA.
  • Pallis P; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Bielecki P; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Low JS; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Zhao J; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.
  • Harman CCD; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA.
  • Kroehling L; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Jackson R; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Bailis W; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Licona-Limón P; Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, México.
  • Xu H; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Iijima N; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Pillai PS; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Koch Institute for Integrative Cancer Research and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Kaplan DH; Department of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  • Weaver CT; Departments of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Kluger Y; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA; Applied Mathematics Program, Yale University, New Haven, CT 06511, USA.
  • Kowalczyk MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Iwasaki A; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA.
  • Pereira JP; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
  • Esplugues E; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Laboratory of Molecular and Cellular Immunology, Principe Felipe Research Center (CIPF), 46012 Valencia, Spain.
  • Gagliani N; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; I. Medical Department and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf 20246 Hamburg, Germany; Immunology and Allergy Unit, Department of Medicine Solna, Karolin
  • Flavell RA; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. Electronic address: richard.flavell@yale.edu.
Cell ; 178(5): 1176-1188.e15, 2019 08 22.
Article em En | MEDLINE | ID: mdl-31442406
Adaptive immunity provides life-long protection by generating central and effector memory T cells and the most recently described tissue resident memory T (TRM) cells. However, the cellular origin of CD4 TRM cells and their contribution to host defense remain elusive. Using IL-17A tracking-fate mouse models, we found that a significant fraction of lung CD4 TRM cells derive from IL-17A-producing effector (TH17) cells following immunization with heat-killed Klebsiella pneumonia (Kp). These exTH17 TRM cells are maintained in the lung by IL-7, produced by lymphatic endothelial cells. During a memory response, neither antibodies, γδ T cells, nor circulatory T cells are sufficient for the rapid host defense required to eliminate Kp. Conversely, using parabiosis and depletion studies, we demonstrated that exTH17 TRM cells play an important role in bacterial clearance. Thus, we delineate the origin and function of airway CD4 TRM cells during bacterial infection, offering novel strategies for targeted vaccine design.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article