Molecular mechanism of TMEM16A regulation: role of CaMKII and PP1/PP2A.

Ayon, Ramon J; Hawn, Matthew B; Aoun, Joydeep; Wiwchar, Michael; Forrest, Abigail S; Cunningham, Fiona; Singer, Cherie A; Valencik, Maria L; Greenwood, Iain A; Leblanc, Normand

Ayon, Ramon J; Hawn, Matthew B; Aoun, Joydeep; Wiwchar, Michael; Forrest, Abigail S; Cunningham, Fiona; Singer, Cherie A; Valencik, Maria L; Greenwood, Iain A; Leblanc, Normand.

Afiliação

Ayon RJ; Division of Translational and Regenerative Medicine, Department of Medicine, College of Medicine, The University of Arizona College of Medicine, Arizona Health Sciences Center, Tucson, Arizona.
Hawn MB; Department of Pharmacology, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.
Aoun J; The Center for Cardiovascular Research, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.
Wiwchar M; Department of Pharmacology, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.
Forrest AS; The Center for Cardiovascular Research, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.
Cunningham F; Department of Pharmacology, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.
Singer CA; Department of Pharmacology, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.
Valencik ML; Department of Pharmacology, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.
Greenwood IA; Department of Pharmacology, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.
Leblanc N; Department of Pharmacology, Center of Biomedical Research Excellence for Molecular and Cellular Signal Transduction in the Cardiovascular System, University of Nevada, Reno School of Medicine, Reno, Nevada.

Am J Physiol Cell Physiol ; 317(6): C1093-C1106, 2019 12 01.

Article em En | MEDLINE | ID: mdl-31461344

Assuntos

Anoctamina-1/genética; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/genética; Regulação da Expressão Gênica; Proteínas de Neoplasias/genética; Proteína Fosfatase 1/genética; Proteína Fosfatase 2/genética; Trifosfato de Adenosina/metabolismo; Trifosfato de Adenosina/farmacologia; Sequência de Aminoácidos; Animais; Anoctamina-1/metabolismo; Benzilaminas/farmacologia; Cálcio/metabolismo; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/antagonistas & inibidores; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Cantaridina/farmacologia; Cloretos/metabolismo; Potenciais Evocados/efeitos dos fármacos; Potenciais Evocados/fisiologia; Células HEK293; Humanos; Transporte de Íons/efeitos dos fármacos; Camundongos; Proteínas de Neoplasias/metabolismo; Ácido Okadáico/farmacologia; Técnicas de Patch-Clamp; Peptídeos/farmacologia; Fosforilação/efeitos dos fármacos; Proteína Fosfatase 1/antagonistas & inibidores; Proteína Fosfatase 1/metabolismo; Proteína Fosfatase 2/antagonistas & inibidores; Proteína Fosfatase 2/metabolismo; Alinhamento de Sequência; Homologia de Sequência de Aminoácidos; Transdução de Sinais; Sulfonamidas/farmacologia

Palavras-chave

Ano-1; CaMKII; TMEM16A; calcium-activated chloride channel; regulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article