The Prediction of the Area under the Curve and Clearance of Midazolam from Single-Point Plasma Concentration and Urinary Excretion in Healthy Volunteers.

Miura, Motoyasu; Uchida, Shinya; Tanaka, Shimako; Inui, Naoki; Kawakami, Junichi; Watanabe, Hiroshi; Namiki, Noriyuki

Miura, Motoyasu; Uchida, Shinya; Tanaka, Shimako; Inui, Naoki; Kawakami, Junichi; Watanabe, Hiroshi; Namiki, Noriyuki.

Afiliação

Miura M; Departments of Pharmacy Practice & Science, School of Pharmaceutical Sciences, University of Shizuoka.
Uchida S; Hospital Pharmacy, Hamamatsu University School of Medicine.
Tanaka S; Departments of Pharmacy Practice & Science, School of Pharmaceutical Sciences, University of Shizuoka.
Inui N; Departments of Pharmacy Practice & Science, School of Pharmaceutical Sciences, University of Shizuoka.
Kawakami J; Department of Clinical Pharmacology & Therapeutics, Hamamatsu University School of Medicine.
Watanabe H; Hospital Pharmacy, Hamamatsu University School of Medicine.
Namiki N; Department of Clinical Pharmacology & Therapeutics, Hamamatsu University School of Medicine.

Biol Pharm Bull ; 42(9): 1590-1595, 2019.

Article em En | MEDLINE | ID: mdl-31474719

Assuntos

Citocromo P-450 CYP3A/metabolismo; Voluntários Saudáveis; Midazolam/administração & dosagem; Midazolam/sangue; Midazolam/urina; Administração Oral; Área Sob a Curva; Estudos Cross-Over; Relação Dose-Resposta a Droga; Humanos; Injeções Intravenosas; Taxa de Depuração Metabólica; Valor Preditivo dos Testes; Estudos Retrospectivos; Fatores de Tempo

Palavras-chave

CYP3A4; midazolam; single-point sampling; urinary excretion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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