Subchronic toxicity of cerium nitrate by 90-day oral exposure in wistar rats.
Regul Toxicol Pharmacol
; 108: 104474, 2019 Nov.
Article
em En
| MEDLINE
| ID: mdl-31494192
ABSTRACT
This study evaluated the subchronic toxicity of cerium nitrate and determined the no observed adverse effect level (NOAEL) in Wistar rats. In accordance with the Organization for Economic Co-operation and Development guidelines, cerium nitrate was orally administered to Wistar rats by gavage at 0, 0.2, 75, 150, and 300â¯mg/kgâ¯bw/day for 90 days, followed by 28 days of recovery period in the 300â¯mg/kgâ¯bw/day and the control groups. The following parameters were evaluated mortality, abnormalities, body weight, food consumption, hematology, serum biochemistry, urinanalysis, gross necropsy and histopathology. At the end of the treatment, several significant changes were observed in the 300â¯mg/kgâ¯bw/day groups relatively decreased mean body weight of males, increased LYMPH%, RET% and decreased NEUT%, RBC of the females, increased ALT, AST and decreased ALB, T-Bil, CHO, CK, LDH of males. Significantly decreased T-Bil, CHO, CK and LDH were also observed in males of the 150â¯mg/kgâ¯bw/day group. Pathological examination revealed that the incidences of foreign body granulomatous lesions in lungs were higher in the 150 and 300â¯mg/kgâ¯bw/day groups as compared with the control group. These findings were attributed to unexpected gavage exposure because the granuloma exhibited a bronchiole-derived distribution. Taken together, the NOAEL of cerium nitrate in Wistar rats is set to be 75â¯mg/kgâ¯bw/day in the present study.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article