Inhibiting microRNA-144 potentiates Nrf2-dependent antioxidant signaling in RPE and protects against oxidative stress-induced outer retinal degeneration.

Jadeja, Ravirajsinh N; Jones, Malita A; Abdelrahman, Ammar A; Powell, Folami L; Thounaojam, Menaka C; Gutsaeva, Diana; Bartoli, Manuela; Martin, Pamela M

Jadeja, Ravirajsinh N; Jones, Malita A; Abdelrahman, Ammar A; Powell, Folami L; Thounaojam, Menaka C; Gutsaeva, Diana; Bartoli, Manuela; Martin, Pamela M.

Afiliação

Jadeja RN; Departments of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA. Electronic address: rjadeja@augusta.edu.
Jones MA; Departments of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Abdelrahman AA; Departments of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA; Department of Clinical Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Powell FL; Departments of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Thounaojam MC; Departments of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Gutsaeva D; Departments of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Bartoli M; Departments of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA; Department of Culver Vision Discovery Institute and Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Martin PM; Departments of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA; Departments of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA; Department of Culver Vision Discovery Institute and Medical College o

Redox Biol ; 28: 101336, 2020 01.

Article em En | MEDLINE | ID: mdl-31590045

Assuntos

Antioxidantes/metabolismo; MicroRNAs/genética; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo; Degeneração Retiniana/etiologia; Degeneração Retiniana/metabolismo; Epitélio Pigmentado da Retina/metabolismo; Transdução de Sinais; Regiões 3' não Traduzidas; Animais; Linhagem Celular; Humanos; Masculino; Camundongos; Modelos Biológicos; Interferência de RNA; Degeneração Retiniana/patologia; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Nrf2; Oxidative stress; RPE; Retinal pigment epithelium; miR-144; microRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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