Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence.

Arata, Yoshiyuki; Watanabe, Ayaka; Motosugi, Ryo; Murakami, Ryuichi; Goto, Tsuyoshi; Hori, Shohei; Hirayama, Shoshiro; Hamazaki, Jun; Murata, Shigeo

Arata, Yoshiyuki; Watanabe, Ayaka; Motosugi, Ryo; Murakami, Ryuichi; Goto, Tsuyoshi; Hori, Shohei; Hirayama, Shoshiro; Hamazaki, Jun; Murata, Shigeo.

Afiliação

Arata Y; Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Watanabe A; Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Motosugi R; Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Murakami R; Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Goto T; Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Hori S; Laboratory of Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Hirayama S; Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Hamazaki J; Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Murata S; Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Genes Cells ; 24(12): 801-813, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31621149

Assuntos

Linfócitos T CD4-Positivos/metabolismo; Senescência Celular; Complexo de Endopeptidases do Proteassoma/metabolismo; Receptores de Antígenos de Linfócitos T/metabolismo; Animais; Linfócitos T CD4-Positivos/fisiologia; Proliferação de Células; Células Cultivadas; Citocinas/genética; Citocinas/metabolismo; Receptores de Hialuronatos/genética; Receptores de Hialuronatos/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fenótipo; Receptor de Morte Celular Programada 1/genética; Receptor de Morte Celular Programada 1/metabolismo; Receptores de Antígenos de Linfócitos T/genética; Transdução de Sinais

Palavras-chave

T cell receptor signal; T cell senescence; aging; proteasome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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