Targeting the Hedgehog pathway in combination with X­ray or carbon ion radiation decreases migration of MCF­7 breast cancer cells.

Konings, Katrien; Belmans, Niels; Vermeesen, Randy; Baselet, Bjorn; Lamers, Greta; Janssen, Ann; Isebaert, Sofie; Baatout, Sarah; Haustermans, Karin; Moreels, Marjan

Targeting the Hedgehog pathway in combination with Xray or carbon ion radiation decreases migration of MCF7 breast cancer cells.

Konings, Katrien; Belmans, Niels; Vermeesen, Randy; Baselet, Bjorn; Lamers, Greta; Janssen, Ann; Isebaert, Sofie; Baatout, Sarah; Haustermans, Karin; Moreels, Marjan.

Afiliação

Konings K; Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCKâ¢CEN), Antwerp, 2400 Mol, Belgium.
Belmans N; Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCKâ¢CEN), Antwerp, 2400 Mol, Belgium.
Vermeesen R; Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCKâ¢CEN), Antwerp, 2400 Mol, Belgium.
Baselet B; Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCKâ¢CEN), Antwerp, 2400 Mol, Belgium.
Lamers G; Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCKâ¢CEN), Antwerp, 2400 Mol, Belgium.
Janssen A; Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCKâ¢CEN), Antwerp, 2400 Mol, Belgium.
Isebaert S; Laboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, FlemishBrabant, 3000 Leuven, Belgium.
Baatout S; Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCKâ¢CEN), Antwerp, 2400 Mol, Belgium.
Haustermans K; Laboratory of Experimental Radiotherapy, Department of Oncology, KU Leuven, FlemishBrabant, 3000 Leuven, Belgium.
Moreels M; Radiobiology Unit, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCKâ¢CEN), Antwerp, 2400 Mol, Belgium.

Int J Oncol ; 55(6): 1339-1348, 2019 Dec.

Article em En | MEDLINE | ID: mdl-31638201

Assuntos

Neoplasias da Mama/terapia; Quimiorradioterapia/métodos; Proteínas Hedgehog/antagonistas & inibidores; Piridinas/farmacologia; Pirimidinas/farmacologia; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Movimento Celular/efeitos da radiação; Proliferação de Células; Sobrevivência Celular; Perfilação da Expressão Gênica; Radioterapia com Íons Pesados/métodos; Proteínas Hedgehog/metabolismo; Humanos; Células MCF-7; Piridinas/uso terapêutico; Pirimidinas/uso terapêutico; Tolerância a Radiação/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/efeitos da radiação; Terapia por Raios X/métodos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article