Anti-hyperuricemia activity and toxicity prediction of a novel xanthine oxidoreductase inhibitor.

Zhou, Liping; Wei, Baxiong; Wu, Lvying; Li, Jing; Zhu, Bin; Zhang, Lei

Zhou, Liping; Wei, Baxiong; Wu, Lvying; Li, Jing; Zhu, Bin; Zhang, Lei.

Afiliação

Zhou L; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.
Wei B; Evaluation and Monitoring Center of Occupational Health, Guangzhou Twelfth People's Hospital, Guangzhou, P. R. China.
Wu L; Evaluation and Monitoring Center of Occupational Health, Guangzhou Twelfth People's Hospital, Guangzhou, P. R. China.
Li J; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.
Zhu B; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.
Zhang L; Analytical and Testing Center, South China University of Technology, Guangzhou, P. R. China.

Biomed Chromatogr ; 34(2): e4727, 2020 Feb.

Article em En | MEDLINE | ID: mdl-31657461

Assuntos

Inibidores Enzimáticos; Hiperuricemia/metabolismo; Xantina Desidrogenase/antagonistas & inibidores; Animais; Biotransformação; Creatinina/sangue; Modelos Animais de Doenças; Inibidores Enzimáticos/química; Inibidores Enzimáticos/metabolismo; Inibidores Enzimáticos/farmacologia; Inibidores Enzimáticos/toxicidade; Rim/efeitos dos fármacos; Rim/metabolismo; Masculino; Camundongos; Ratos; Ratos Sprague-Dawley

Palavras-chave

inhibitor; metabolite; renal histopathology; serum biochemical assay; xanthine oxidoreductase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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