The effects of indomethacin and verapamil on the shape changes of vascular endothelial cells resulting from exposure to various inflammatory agents.
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; 24(3-4): 351-5, 1988 Jul.
Article
em En
| MEDLINE
| ID: mdl-3177095
ABSTRACT
Histamine (300 microM), bradykinin (2 microM), prostaglandin E2 (PGE2) (30 microM), or the leukotrienes (LT) C4 and E4 (1 microM) but not D4 (1 microM) applied in vitro have been shown to change the shape of endothelial cells lining the guinea pig isolated thoracic inferior vena cava. All caused the formation of inter-endothelial cell gaps. Pre-treatment with either indomethacin (100 microM) or verapamil (20 microM) reduced the effects of these compounds. It is suggested that indomethacin and verapamil act by reducing the amount of intracellular calcium available for the shortening of contractile protein filaments within endothelial cells.
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01-internacional
Base de dados:
MEDLINE
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article