ß-Catenin Is Required for the cGAS/STING Signaling Pathway but Antagonized by the Herpes Simplex Virus 1 US3 Protein.

You, Hongjuan; Lin, Yingying; Lin, Feng; Yang, Mingyue; Li, Jiahui; Zhang, Rongzhao; Huang, Zhiming; Shen, Qingtang; Tang, Renxian; Zheng, Chunfu

You, Hongjuan; Lin, Yingying; Lin, Feng; Yang, Mingyue; Li, Jiahui; Zhang, Rongzhao; Huang, Zhiming; Shen, Qingtang; Tang, Renxian; Zheng, Chunfu.

Afiliação

You H; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Lin Y; Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Lin F; Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Yang M; Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Li J; Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Zhang R; Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Huang Z; Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Shen Q; Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Tang R; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Zheng C; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.

J Virol ; 94(5)2020 02 14.

Article em En | MEDLINE | ID: mdl-31801859

Assuntos

Herpesvirus Humano 1/metabolismo; Proteínas de Membrana/metabolismo; Nucleotidiltransferases/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Transdução de Sinais; Proteínas Virais/metabolismo; beta Catenina/metabolismo; Células A549; Animais; Chlorocebus aethiops; Citocinas; Regulação para Baixo; Técnicas de Inativação de Genes; Células HEK293; Humanos; Imunidade Inata; Interferon Tipo I/metabolismo; Proteínas de Membrana/genética; Nucleotidiltransferases/genética; Fosforilação; Células Vero; beta Catenina/genética

Palavras-chave

HSV-1; US3; type I IFN; ß-catenin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article