p-Coumaric Acid Attenuates IL-1ß-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.

Huang, Xiaojian; You, Yingqian; Xi, Yang; Ni, Bowei; Chu, Xiangyu; Zhang, Rui; You, Hongbo

Huang, Xiaojian; You, Yingqian; Xi, Yang; Ni, Bowei; Chu, Xiangyu; Zhang, Rui; You, Hongbo.

Afiliação

Huang X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095#, Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
You Y; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 1095#, Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Xi Y; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095#, Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Ni B; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095#, Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Chu X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095#, Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
Zhang R; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095#, Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China.
You H; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095#, Jiefang Avenue, Qiaokou District, Wuhan, 430030, Hubei, China. hbyou360@hotmail.com.

Inflammation ; 43(2): 619-628, 2020 Apr.

Article em En | MEDLINE | ID: mdl-31823179

Assuntos

Senescência Celular/efeitos dos fármacos; Condrócitos/efeitos dos fármacos; Sequestradores de Radicais Livres/farmacologia; Mediadores da Inflamação/antagonistas & inibidores; Interleucina-1beta/toxicidade; Propionatos/farmacologia; Animais; Animais Recém-Nascidos; Sobrevivência Celular/efeitos dos fármacos; Sobrevivência Celular/fisiologia; Células Cultivadas; Senescência Celular/fisiologia; Condrócitos/imunologia; Condrócitos/metabolismo; Ácidos Cumáricos; Relação Dose-Resposta a Droga; Mediadores da Inflamação/imunologia; Mediadores da Inflamação/metabolismo; Masculino; Ratos; Ratos Sprague-Dawley

Palavras-chave

IL-1ß; MAPK; NF-κB; inflammation; osteoarthritis; senescence

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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