Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson's disease.

Koutzoumis, Dimitri N; Vergara, Macarena; Pino, Jose; Buddendorff, Julia; Khoshbouei, Habibeh; Mandel, Ronald J; Torres, Gonzalo E

Koutzoumis, Dimitri N; Vergara, Macarena; Pino, Jose; Buddendorff, Julia; Khoshbouei, Habibeh; Mandel, Ronald J; Torres, Gonzalo E.

Afiliação

Koutzoumis DN; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, 1200 Newell Drive, Gainesville, FL 32610., United States of America.
Vergara M; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, 1200 Newell Drive, Gainesville, FL 32610., United States of America.
Pino J; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, 1200 Newell Drive, Gainesville, FL 32610., United States of America; Department of Medicine, School of Medicine, University of Atacama, 1581 Los Carrera Ave, Copiapo, Chile.
Buddendorff J; Department of Pharmacology and Therapeutics, University of Florida College of Medicine, 1200 Newell Drive, Gainesville, FL 32610., United States of America.
Khoshbouei H; Department of Neuroscience, University of Florida College of Medicine, 1149 Newell Drive, Gainesville, FL 32610, United States of America.
Mandel RJ; Department of Neuroscience, University of Florida College of Medicine, 1149 Newell Drive, Gainesville, FL 32610, United States of America.
Torres GE; Department of Molecular, Cellular, and Biomedical Sciences, City University of New York School of Medicine at City College, 160 Convent Ave, NY, New York 10031, United States of America. Electronic address: gtorres@med.cuny.edu.

Exp Neurol ; 325: 113159, 2020 03.

Article em En | MEDLINE | ID: mdl-31843492

Assuntos

Antibacterianos/farmacologia; Neurônios Dopaminérgicos/patologia; Microbioma Gastrointestinal/efeitos dos fármacos; Degeneração Neural/patologia; Transtornos Parkinsonianos/patologia; Animais; Bacitracina/farmacologia; Masculino; Atividade Motora/efeitos dos fármacos; Natamicina/farmacologia; Neomicina/farmacologia; Degeneração Neural/etiologia; Transtornos Parkinsonianos/complicações; Transtornos Parkinsonianos/microbiologia; Ratos; Ratos Sprague-Dawley; Vancomicina/farmacologia

Palavras-chave

Antibiotics; Dopamine; Gut; Microbiota; Neuron; Parkinson's disease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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