Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli.

Garoff, Linnéa; Pietsch, Franziska; Huseby, Douglas L; Lilja, Tua; Brandis, Gerrit; Hughes, Diarmaid

Garoff, Linnéa; Pietsch, Franziska; Huseby, Douglas L; Lilja, Tua; Brandis, Gerrit; Hughes, Diarmaid.

Afiliação

Garoff L; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Pietsch F; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Huseby DL; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Lilja T; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Brandis G; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.
Hughes D; Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden.

Mol Biol Evol ; 37(6): 1637-1646, 2020 06 01.

Article em En | MEDLINE | ID: mdl-32031639

Assuntos

Antibacterianos; Farmacorresistência Bacteriana/genética; Escherichia coli/genética; Evolução Molecular; Fluoroquinolonas; Ligação Genética; Fenótipo; Sequenciamento Completo do Genoma

Palavras-chave

Escherichia coli; antibiotic resistance; bottleneck size; ciprofloxacin; experimental evolution; mutation supply

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article