Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators.

Hong, Fan; Ma, Duo; Wu, Kaiyue; Mina, Lida A; Luiten, Rebecca C; Liu, Yan; Yan, Hao; Green, Alexander A

Hong, Fan; Ma, Duo; Wu, Kaiyue; Mina, Lida A; Luiten, Rebecca C; Liu, Yan; Yan, Hao; Green, Alexander A.

Afiliação

Hong F; Biodesign Center for Molecular Design and Biomimetics at the Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
Ma D; Biodesign Center for Molecular Design and Biomimetics at the Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
Wu K; Biodesign Center for Molecular Design and Biomimetics at the Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
Mina LA; Hematology-Oncology Department, Banner MD Anderson Cancer Center, Gilbert, AZ 85234, USA.
Luiten RC; Genetics Department, Banner MD Anderson Cancer Center, Gilbert, AZ 85234, USA.
Liu Y; Biodesign Center for Molecular Design and Biomimetics at the Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
Yan H; Biodesign Center for Molecular Design and Biomimetics at the Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA. Electronic address: hao.yan@asu.edu.
Green AA; Biodesign Center for Molecular Design and Biomimetics at the Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA. Electronic address: alexgreen@asu.edu.

Cell ; 180(5): 1018-1032.e16, 2020 03 05.

Article em En | MEDLINE | ID: mdl-32109416

Assuntos

Epigenômica; Polimorfismo de Nucleotídeo Único/genética; RNA/genética; Transcriptoma/genética; Resistência a Medicamentos/genética; Escherichia coli/genética; Regulação da Expressão Gênica/genética; Humanos; Mutação/genética; Neoplasias/genética; Conformação de Ácido Nucleico; Células Procarióticas/metabolismo; Biologia Sintética; Zika virus/genética; Zika virus/isolamento & purificação; Zika virus/patogenicidade

Palavras-chave

colorimetric; diagnostic; isothermal; mutation; paper-based assay; riboregulator; specificity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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