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Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast.
Onwubiko, Udo N; Rich-Robinson, Julie; Mustaf, Rose Albu; Das, Maitreyi E.
Afiliação
  • Onwubiko UN; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA.
  • Rich-Robinson J; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA.
  • Mustaf RA; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA.
  • Das ME; Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA.
Small GTPases ; 12(4): 257-264, 2021 07.
Article em En | MEDLINE | ID: mdl-32182184
Cytokinesis in fission yeast involves actomyosin ring constriction concurrent to septum synthesis followed by septum digestion resulting in cell separation. A recent report indicates that endocytosis is required for septum synthesis and cell separation. The conserved GTPase Cdc42 is required for membrane trafficking and promotes endocytosis. Cdc42 is activated by Guanine nucleotide exchange factors (GEFs). Cdc42 GEFs have been shown to promote timely initiation of septum synthesis and proper septum morphology. Here we show that Cdc42 promotes the recruitment of the major primary septum synthesizing enzyme Bgs1 and consequent ring constriction. Cdc42 is also required for proper localization of the septum digesting glucanases at the division site. Thus, Cdc42 is required to promote multiple steps during cytokinesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article