FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.

Juvvadi, Praveen R; Bobay, Benjamin G; Gobeil, Sophie M C; Cole, D Christopher; Venters, Ronald A; Heitman, Joseph; Spicer, Leonard D; Steinbach, William J

Juvvadi, Praveen R; Bobay, Benjamin G; Gobeil, Sophie M C; Cole, D Christopher; Venters, Ronald A; Heitman, Joseph; Spicer, Leonard D; Steinbach, William J.

Afiliação

Juvvadi PR; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address: praveen.juvvadi@duke.edu.
Bobay BG; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA; Department of Biochemistry, Durham, NC, 27710, USA; Department of Radiology, Duke University, Durham, NC, 27710, USA.
Gobeil SMC; Department of Biochemistry, Durham, NC, 27710, USA; Department of Radiology, Duke University, Durham, NC, 27710, USA.
Cole DC; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA.
Venters RA; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA; Department of Biochemistry, Durham, NC, 27710, USA; Department of Radiology, Duke University, Durham, NC, 27710, USA.
Heitman J; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA.
Spicer LD; Duke University NMR Center, Duke University Medical Center, Durham, NC, 27710, USA; Department of Biochemistry, Durham, NC, 27710, USA; Department of Radiology, Duke University, Durham, NC, 27710, USA.
Steinbach WJ; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address: bill.steinbach@duke.edu.

Biochem Biophys Res Commun ; 526(1): 48-54, 2020 05 21.

Article em En | MEDLINE | ID: mdl-32192767

Assuntos

Aspergillus fumigatus/metabolismo; Inibidores de Calcineurina/farmacologia; Calcineurina/metabolismo; Proteínas Fúngicas/genética; Mutação/genética; Multimerização Proteica; Proteína 1A de Ligação a Tacrolimo/genética; Tacrolimo/farmacologia; Sequência de Aminoácidos; Simulação por Computador; Proteínas Fúngicas/química; Proteínas Fúngicas/metabolismo; Humanos; Proteínas Mutantes/química; Proteínas Mutantes/metabolismo; Ligação Proteica/efeitos dos fármacos; Estrutura Secundária de Proteína; Proteína 1A de Ligação a Tacrolimo/química; Proteína 1A de Ligação a Tacrolimo/metabolismo

Palavras-chave

Aspergillus; Calcineurin; Dimerization; FK506; FKBP12; Molecular dynamics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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