Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain.

Zhou, Ya-Qun; Liu, Dai-Qiang; Chen, Shu-Ping; Chen, Nan; Sun, Jia; Wang, Xiao-Mei; Cao, Fei; Tian, Yu-Ke; Ye, Da-Wei

Zhou, Ya-Qun; Liu, Dai-Qiang; Chen, Shu-Ping; Chen, Nan; Sun, Jia; Wang, Xiao-Mei; Cao, Fei; Tian, Yu-Ke; Ye, Da-Wei.

Afiliação

Zhou YQ; Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Liu DQ; Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Chen SP; Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Chen N; Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Sun J; Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wang XM; Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Cao F; Department of Psychiatry, UMKC School of Medicine, Kansas City, MO, 64108, USA.
Tian YK; Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. yktian@tjh.tjmu.edu.cn.
Ye DW; Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. dy0711@gmail.com.

Acta Pharmacol Sin ; 41(8): 1041-1048, 2020 Aug.

Article em En | MEDLINE | ID: mdl-32203087

Assuntos

Analgésicos; Hiperalgesia; Fator 2 Relacionado a NF-E2; Neuralgia; Pirazinas; Tionas; Tiofenos; Animais; Ratos; Alcaloides/farmacologia; Analgésicos/uso terapêutico; Heme Oxigenase (Desciclizante)/metabolismo; Hiperalgesia/tratamento farmacológico; Hiperalgesia/prevenção & controle; Neuralgia/induzido quimicamente; Neuralgia/tratamento farmacológico; Neuralgia/prevenção & controle; Paclitaxel; Pirazinas/uso terapêutico; Medula Espinal/metabolismo; Tionas/uso terapêutico; Tiofenos/uso terapêutico; Regulação para Cima/efeitos dos fármacos; Fator 2 Relacionado a NF-E2/agonistas; Fator 2 Relacionado a NF-E2/antagonistas & inibidores

Palavras-chave

HO-1; Nrf2; neuropathic pain; oltipraz; oxidative stress; paclitaxel

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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