Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir.

Yu, Huixin; Janssen, Julie M; de Weger, Vincent A; Nuijen, Bastiaan; Stuurman, Rik E; Marchetti, Serena; Schellens, Jan H M; Beijnen, Jos H; Dorlo, Thomas P C; Huitema, Alwin D R

Yu, Huixin; Janssen, Julie M; de Weger, Vincent A; Nuijen, Bastiaan; Stuurman, Rik E; Marchetti, Serena; Schellens, Jan H M; Beijnen, Jos H; Dorlo, Thomas P C; Huitema, Alwin D R.

Afiliação

Yu H; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
Janssen JM; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands. ju.janssen@nki.nl.
de Weger VA; Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nuijen B; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
Stuurman RE; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
Marchetti S; Centre for Human Drug Research, Leiden, The Netherlands.
Schellens JHM; Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Beijnen JH; Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Dorlo TPC; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Huitema ADR; Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

Invest New Drugs ; 38(5): 1526-1532, 2020 10.

Article em En | MEDLINE | ID: mdl-32306204

Assuntos

Antineoplásicos; Protocolos de Quimioterapia Combinada Antineoplásica; Docetaxel; Modelos Biológicos; Ritonavir; Administração Oral; Antineoplásicos/administração & dosagem; Antineoplásicos/efeitos adversos; Antineoplásicos/farmacocinética; Antineoplásicos/toxicidade; Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Protocolos de Quimioterapia Combinada Antineoplásica/farmacocinética; Protocolos de Quimioterapia Combinada Antineoplásica/toxicidade; Simulação por Computador; Docetaxel/administração & dosagem; Docetaxel/efeitos adversos; Docetaxel/farmacocinética; Docetaxel/toxicidade; Humanos; Ritonavir/administração & dosagem; Ritonavir/efeitos adversos; Ritonavir/farmacocinética; Ritonavir/toxicidade

Palavras-chave

Docetaxel; Oral formulation; Pharmacokinetics; Ritonavir; Toxicodynamics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article