RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner.

Guo, Xingya; Li, Kai; Jiang, Weiliang; Hu, Yangyang; Xiao, Wenqin; Huang, Yinshi; Feng, Yun; Pan, Qin; Wan, Rong

Guo, Xingya; Li, Kai; Jiang, Weiliang; Hu, Yangyang; Xiao, Wenqin; Huang, Yinshi; Feng, Yun; Pan, Qin; Wan, Rong.

Afiliação

Guo X; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People's Republic of China.
Li K; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People's Republic of China.
Jiang W; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People's Republic of China.
Hu Y; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People's Republic of China.
Xiao W; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People's Republic of China.
Huang Y; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People's Republic of China.
Feng Y; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People's Republic of China.
Pan Q; Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665, Kongjiang Road, Shanghai, 200092, People's Republic of China. panqin@xinhuamed.com.cn.
Wan R; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100, Haining Road, Shanghai, 200080, People's Republic of China. rong.wan@shgh.cn.

Mol Cancer ; 19(1): 91, 2020 05 19.

Article em En | MEDLINE | ID: mdl-32429928

Assuntos

Adenosina/análogos & derivados; Homólogo AlkB 5 da RNA Desmetilase/metabolismo; Regulação Neoplásica da Expressão Gênica; Neoplasias Pancreáticas/patologia; Proteínas Circadianas Period/genética; Proteínas de Ligação a RNA/metabolismo; Ativação Transcricional; Adenosina/química; Homólogo AlkB 5 da RNA Desmetilase/genética; Animais; Apoptose; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Movimento Celular; Proliferação de Células; Feminino; Humanos; Masculino; Camundongos; Camundongos Nus; Pessoa de Meia-Idade; Invasividade Neoplásica; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Proteínas Circadianas Period/metabolismo; Prognóstico; Processamento Pós-Transcricional do RNA; Proteínas de Ligação a RNA/genética; Taxa de Sobrevida; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

ALKBH5; PER1; Pancreatic cancer; m6A

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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