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Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure.
Dyavanapalli, Jhansi; Rodriguez, Jeannette; Rocha Dos Santos, Carla; Escobar, Joan B; Dwyer, Mary Kate; Schloen, John; Lee, Kyung-Min; Wolaver, Whitney; Wang, Xin; Dergacheva, Olga; Michelini, Lisete C; Schunke, Kathryn J; Spurney, Christopher F; Kay, Matthew W; Mendelowitz, David.
Afiliação
  • Dyavanapalli J; Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Rodriguez J; Department of Biomedical Engineering, George Washington University, Washington, DC.
  • Rocha Dos Santos C; Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Escobar JB; Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Dwyer MK; Department of Biomedical Engineering, George Washington University, Washington, DC.
  • Schloen J; Department of Biomedical Engineering, George Washington University, Washington, DC.
  • Lee KM; Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Wolaver W; Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Wang X; Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Dergacheva O; Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Michelini LC; Department of Physiology, Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo/SP, Brazil.
  • Schunke KJ; Department of Biomedical Engineering, George Washington University, Washington, DC.
  • Spurney CF; Children's National Heart Institute, Center for Genetic Medicine Research, Children's National Health System, Washington, DC.
  • Kay MW; Department of Biomedical Engineering, George Washington University, Washington, DC.
  • Mendelowitz D; Department of Pharmacology and Physiology, George Washington University, Washington, DC.
JACC Basic Transl Sci ; 5(5): 484-497, 2020 May.
Article em En | MEDLINE | ID: mdl-32478209
ABSTRACT
This work shows long-term restoration of the hypothalamic oxytocin (OXT) network preserves OXT release, reduces mortality, cardiac inflammation, fibrosis, and improves autonomic tone and cardiac function in a model of heart failure. Intranasal administration of OXT in patients mimics the short-term changes seen in animals by increasing parasympathetic-and decreasing sympathetic-cardiac activity. This work provides the essential translational foundation to determine if approaches that mimic paraventricular nucleus (PVN) OXT neuron activation, such as safe, noninvasive, and well-tolerated intranasal administration of OXT, can be beneficial in patients with heart failure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article