Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation.

Laprade, Hadrien; Querido, Emmanuelle; Smith, Michael Joseph; Guérit, David; Crimmins, Hannah; Conomos, Dimitri; Pourret, Emilie; Chartrand, Pascal; Sfeir, Agnel

Laprade, Hadrien; Querido, Emmanuelle; Smith, Michael Joseph; Guérit, David; Crimmins, Hannah; Conomos, Dimitri; Pourret, Emilie; Chartrand, Pascal; Sfeir, Agnel.

Afiliação

Laprade H; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Querido E; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Smith MJ; Skirball Institute of Biomolecular Medicine, Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA.
Guérit D; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Crimmins H; Skirball Institute of Biomolecular Medicine, Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA.
Conomos D; Skirball Institute of Biomolecular Medicine, Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA.
Pourret E; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada.
Chartrand P; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC H3C 3J7, Canada. Electronic address: p.chartrand@umontreal.ca.
Sfeir A; Skirball Institute of Biomolecular Medicine, Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA. Electronic address: agnel.sfeir@med.nyu.edu.

Mol Cell ; 79(1): 115-126.e6, 2020 07 02.

Article em En | MEDLINE | ID: mdl-32497497

Assuntos

Corpos Enovelados/metabolismo; DNA de Cadeia Simples/metabolismo; RNA/metabolismo; Imagem Individual de Molécula/métodos; Telomerase/metabolismo; Homeostase do Telômero; Telômero/metabolismo; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas; DNA de Cadeia Simples/genética; Edição de Genes; Células HeLa; Humanos; Mutação; RNA/genética; Complexo Shelterina; Telomerase/genética; Telômero/genética; Proteínas de Ligação a Telômeros/genética; Proteínas de Ligação a Telômeros/metabolismo

Palavras-chave

ATM; ATR; POT1; cancer cellsC; fluorescent in situ hybridization; hTR RNA; single-molecule imaging; telomerase; telomeres

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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