Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades.
Chem Commun (Camb)
; 56(57): 7949-7952, 2020 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-32531011
ABSTRACT
Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion of N-Cbz-protected l-ornithinol and l-lysinol to l-3-N-Cbz-aminopiperidine and l-3-N-Cbz-aminoazepane respectively, in up to 54% isolated yield. Streamlining the reactions into one-pot prevented potential racemisation of key labile intermediates and led to products with high enantiopurity.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article