Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.

Leonards, Katharina; Almosailleakh, Marwa; Tauchmann, Samantha; Bagger, Frederik Otzen; Thirant, Cécile; Juge, Sabine; Bock, Thomas; Méreau, Hélène; Bezerra, Matheus F; Tzankov, Alexandar; Ivanek, Robert; Losson, Régine; Peters, Antoine H F M; Mercher, Thomas; Schwaller, Juerg

Leonards, Katharina; Almosailleakh, Marwa; Tauchmann, Samantha; Bagger, Frederik Otzen; Thirant, Cécile; Juge, Sabine; Bock, Thomas; Méreau, Hélène; Bezerra, Matheus F; Tzankov, Alexandar; Ivanek, Robert; Losson, Régine; Peters, Antoine H F M; Mercher, Thomas; Schwaller, Juerg.

Afiliação

Leonards K; University Children's Hospital Basel, Basel, Switzerland.
Almosailleakh M; Department of Biomedicine, University of Basel, 4031, Basel, Switzerland.
Tauchmann S; University Children's Hospital Basel, Basel, Switzerland.
Bagger FO; Department of Biomedicine, University of Basel, 4031, Basel, Switzerland.
Thirant C; University Children's Hospital Basel, Basel, Switzerland.
Juge S; Department of Biomedicine, University of Basel, 4031, Basel, Switzerland.
Bock T; University Children's Hospital Basel, Basel, Switzerland.
Méreau H; Department of Biomedicine, University of Basel, 4031, Basel, Switzerland.
Bezerra MF; Swiss Institute of Bioinfomatics, 4031, Basel, Switzerland.
Tzankov A; Genomic Medicine, Righospitalet, University of Copenhagen, 2100, Copenhagen, Denmark.
Ivanek R; INSERM U1170, Equipe Labellisée Ligue Contre le Cancer, Gustave Roussy Institute, Université Paris Diderot, Université Paris-Sud, Villejuif, 94800, France.
Losson R; University Children's Hospital Basel, Basel, Switzerland.
Peters AHFM; Department of Biomedicine, University of Basel, 4031, Basel, Switzerland.
Mercher T; Proteomics Core Facility, Biozentrum University of Basel, Basel, Switzerland.
Schwaller J; Department of Biomedicine, University of Basel, 4031, Basel, Switzerland.

Nat Commun ; 11(1): 2807, 2020 06 12.

Article em En | MEDLINE | ID: mdl-32533074

Assuntos

Diferenciação Celular; Células Eritroides/metabolismo; Células Eritroides/patologia; Fator de Transcrição GATA1/metabolismo; Histona-Lisina N-Metiltransferase/metabolismo; Leucemia Eritroblástica Aguda/metabolismo; Leucemia Eritroblástica Aguda/patologia; Adulto; Animais; Antígenos CD/metabolismo; Antígenos CD34/metabolismo; Linhagem Celular Tumoral; Linhagem da Célula; Cromatina/metabolismo; Proteínas de Ligação a DNA/metabolismo; Eritroblastos/metabolismo; Fator de Transcrição GATA1/genética; Regulação Leucêmica da Expressão Gênica; Técnicas de Silenciamento de Genes; Hematopoese; Histona-Lisina N-Metiltransferase/genética; Humanos; Estimativa de Kaplan-Meier; Leucemia Eritroblástica Aguda/genética; Masculino; Camundongos; Ligação Proteica; Proteínas Proto-Oncogênicas/metabolismo; Proteínas Proto-Oncogênicas c-kit/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Receptores da Transferrina/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adult / Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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