Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway.

Yao, Yizhou; Wang, Xuchao; Zhou, Diyuan; Li, Hao; Qian, Huan; Zhang, Jiawen; Jiang, Linhua; Wang, Bin; Lin, Qi; Zhu, Xinguo

Yao, Yizhou; Wang, Xuchao; Zhou, Diyuan; Li, Hao; Qian, Huan; Zhang, Jiawen; Jiang, Linhua; Wang, Bin; Lin, Qi; Zhu, Xinguo.

Afiliação

Yao Y; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Wang X; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhou D; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Li H; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Qian H; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhang J; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jiang L; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Wang B; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Lin Q; Suzhou Emergency Center, Suzhou, Jiangsu, China.
Zhu X; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Aging (Albany NY) ; 12(13): 13059-13075, 2020 07 02.

Article em En | MEDLINE | ID: mdl-32615540

Assuntos

Aldo-Ceto Redutases/metabolismo; Movimento Celular/genética; Proliferação de Células/genética; Neoplasias Colorretais; Fator 1 de Crescimento de Fibroblastos/metabolismo; Aldo-Ceto Redutases/genética; Animais; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/patologia; Feminino; Fator 1 de Crescimento de Fibroblastos/genética; Técnicas de Silenciamento de Genes; Genes Supressores de Tumor; Células HCT116; Células HT29; Humanos; Masculino; Camundongos Endogâmicos BALB C; Camundongos Nus; Pessoa de Meia-Idade; Transdução de Sinais/genética

Palavras-chave

AKR1B10; FGF1; colorectal cancer; targeted therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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