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The induction and function of the anti-inflammatory fate of TH17 cells.
Xu, Hao; Agalioti, Theodora; Zhao, Jun; Steglich, Babett; Wahib, Ramez; Vesely, Maria Carolina Amezcua; Bielecki, Piotr; Bailis, Will; Jackson, Ruaidhri; Perez, Daniel; Izbicki, Jakob; Licona-Limón, Paula; Kaartinen, Vesa; Geginat, Jens; Esplugues, Enric; Tolosa, Eva; Huber, Samuel; Flavell, Richard A; Gagliani, Nicola.
Afiliação
  • Xu H; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • Agalioti T; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Zhao J; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • Steglich B; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Wahib R; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Vesely MCA; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • Bielecki P; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • Bailis W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Jackson R; Division of Protective Immunity, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
  • Perez D; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, 06520, USA.
  • Izbicki J; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Licona-Limón P; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Kaartinen V; Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, D.F, México.
  • Geginat J; Biologic and Material Sciences, University of Michigan, 1011N. University Ave, Ann Arbor, MI, 48109, USA.
  • Esplugues E; INGM-National Institute of Molecular Genetics "Romeo ed Enrica Invernizzi", Milan, Italy.
  • Tolosa E; Department of Clinical Sciences and Community Health, Università degli studi di Milano, Milan, Italy.
  • Huber S; Laboratory of Molecular and Cellular Immunology, Principe Felipe Research Center (CIPF), 46012, Valencia, Spain.
  • Flavell RA; Institute of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Gagliani N; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Nat Commun ; 11(1): 3334, 2020 07 03.
Article em En | MEDLINE | ID: mdl-32620760
TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-ß signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article