Peripheral T-cell lymphoma presenting with angioedema and diffuse pulmonary infiltrates.

ABSTRACT

Peripheral T-cell lymphoma is becoming increasingly recognized as a clinical entity despite its protean clinical manifestations and morphological features. Pulmonary involvement is evident in 20% of patients at initial diagnosis and develops in a further 20% during the course of their disease. Angioedema resulting from immune-mediated complement depletion is a rare complication of B-cell tumors. It has not been reported in T-cell lymphoma. We describe a patient with peripheral T-cell lymphoma who presented with angioedema and diffuse pulmonary infiltrates. Normal serum complement levels suggest that this patient developed angioedema independent of abnormalities in the complement cascade.