Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors.

Kogot-Levin, Aviram; Hinden, Liad; Riahi, Yael; Israeli, Tal; Tirosh, Boaz; Cerasi, Erol; Mizrachi, Ernesto Bernal; Tam, Joseph; Mosenzon, Ofri; Leibowitz, Gil

Kogot-Levin, Aviram; Hinden, Liad; Riahi, Yael; Israeli, Tal; Tirosh, Boaz; Cerasi, Erol; Mizrachi, Ernesto Bernal; Tam, Joseph; Mosenzon, Ofri; Leibowitz, Gil.

Afiliação

Kogot-Levin A; Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Hinden L; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Riahi Y; Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Israeli T; Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Tirosh B; Stress Signaling Laboratory, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.
Cerasi E; Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Mizrachi EB; Department of Internal Medicine, Division of Endocrinology, Metabolism and Diabetes, Miller School of Medicine, University of Miami, Miami, FL, USA.
Tam J; Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Mosenzon O; Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Leibowitz G; Diabetes Unit and Endocrine Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: gleib@hadassah.org.il.

Cell Rep ; 32(4): 107954, 2020 07 28.

Article em En | MEDLINE | ID: mdl-32726619

Assuntos

Nefropatias Diabéticas/fisiopatologia; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Inibidores do Transportador 2 de Sódio-Glicose/farmacologia; Animais; Diabetes Mellitus Tipo 2/metabolismo; Nefropatias Diabéticas/etiologia; Humanos; Hipoglicemiantes/farmacologia; Rim/metabolismo; Falência Renal Crônica/metabolismo; Túbulos Renais Proximais/efeitos dos fármacos; Túbulos Renais Proximais/metabolismo; Túbulos Renais Proximais/fisiopatologia; Masculino; Alvo Mecanístico do Complexo 1 de Rapamicina/fisiologia; Camundongos; Inibidores do Transportador 2 de Sódio-Glicose/metabolismo; Suínos

Palavras-chave

SGLT2 inhibitors; complications; diabetes; diabetic kidney disease; fibrosis; mTOR; signal transduction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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