Microwave-Assisted Copper Catalysis of &#945;-Difluorinated <i>gem</i>-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of <i>para</i>-Quinone Methides.

Qu, Chuan-Hua; Song, Gui-Ting; Tang, Dian-Yong; Shao, Jing-Wei; Li, Hong-Yu; Xu, Zhi-Gang; Chen, Zhong-Zhu

Microwave-Assisted Copper Catalysis of α-Difluorinated gem-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of para-Quinone Methides.

Qu, Chuan-Hua; Song, Gui-Ting; Tang, Dian-Yong; Shao, Jing-Wei; Li, Hong-Yu; Xu, Zhi-Gang; Chen, Zhong-Zhu.

Afiliação

Qu CH; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Song GT; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Tang DY; Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
Shao JW; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.
Li HY; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
Xu ZG; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
Chen ZZ; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing 402160, China.

J Org Chem ; 85(19): 12785-12796, 2020 10 02.

Article em En | MEDLINE | ID: mdl-32847359

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article