Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer.

Hall, Peter E; Ready, Neal; Johnston, Amanda; Bomalaski, John S; Venhaus, Ralph R; Sheaff, Michael; Krug, Lee; Szlosarek, Peter W

Hall, Peter E; Ready, Neal; Johnston, Amanda; Bomalaski, John S; Venhaus, Ralph R; Sheaff, Michael; Krug, Lee; Szlosarek, Peter W.

Afiliação

Hall PE; Department of Medical Oncology, Barts Health NHS Trust, London, United Kingdom.
Ready N; Department of Medicine, Duke University Medical Center, Durham, NC.
Johnston A; Medical Affairs, Polaris Pharmaceuticals Inc., San Diego, CA.
Bomalaski JS; Medical Affairs, Polaris Pharmaceuticals Inc., San Diego, CA.
Venhaus RR; Cancer Trials Management, Ludwig Institute for Cancer Research, New York, NY.
Sheaff M; Department of Pathology, Barts Health NHS Trust, London, United Kingdom.
Krug L; Department of Medicine, Thoracic Oncology Service, Division of Solid Tumor Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY.
Szlosarek PW; Department of Medical Oncology, Barts Health NHS Trust, London, United Kingdom; Centre for Molecular Oncology, Queen Mary University of London, London, United Kingdom. Electronic address: p.w.szlosarek@qmul.ac.uk.

Clin Lung Cancer ; 21(6): 527-533, 2020 11.

Article em En | MEDLINE | ID: mdl-32859536

Assuntos

Arginina/deficiência; Resistencia a Medicamentos Antineoplásicos; Hidrolases/uso terapêutico; Neoplasias Pulmonares/tratamento farmacológico; Recidiva Local de Neoplasia/tratamento farmacológico; Polietilenoglicóis/uso terapêutico; Terapia de Salvação; Carcinoma de Pequenas Células do Pulmão/tratamento farmacológico; Idoso; Idoso de 80 Anos ou mais; Estudos de Casos e Controles; Feminino; Seguimentos; Humanos; Neoplasias Pulmonares/patologia; Masculino; Pessoa de Meia-Idade; Recidiva Local de Neoplasia/patologia; Ensaios Clínicos Controlados não Aleatórios como Assunto; Prognóstico; Estudos Retrospectivos; Carcinoma de Pequenas Células do Pulmão/patologia

Palavras-chave

ADI-PEG 20; Argininosuccinate synthetase 1; Auxotropy; Biomarker; SCLC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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