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[Clinical cure strategies for hepatitis B: direct-acting antiviral drugs].
Huang, A L; Yuan, Z H; Nan, Y M; Yang, D L; Guo, J T; Li, W H.
Afiliação
  • Huang AL; Institute for Viral Hepatitis, Chongqing Medical University, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing 400016, China.
  • Yuan ZH; Shanghai Medical College, Fudan University, Shanghai 200032, China.
  • Nan YM; Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
  • Guo JT; Institute of Biotechnology and Virology, Drexel University College of Medicine, Philadelphia, USA.
  • Li WH; National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research (TIMBR), Tsinghua University, Beijing 102206, China.
Zhonghua Gan Zang Bing Za Zhi ; 28(8): 640-644, 2020 Aug 20.
Article em Zh | MEDLINE | ID: mdl-32911899
Direct-acting antivirals (DAAs) play a critical role for the therapy of chronical hepatitis B. DAAs can decrease the production of viral progeny of hepatitis B virus (HBV), breaking the viral dynamic equilibrium between: (1) virion production from hepatocytes and clearance from circulation; (2) replenishment and decay of covalently closed circular (ccc)DNA pool inside infected hepatocytes. Nucleos(t)ide analogues can potently shift the first balance to undetectable viremia in the blood, but have limited or no effect on the second one, thus making it imperative to develop new agents targeting additional step(s) of HBV life cycle. We herein briefly introduce the DAAs currently in development by classifying them as agents affecting the replenishment or the decay of cccDNA pool.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: Zh Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: Zh Ano de publicação: 2020 Tipo de documento: Article