Allosteric inhibition of MTHFR prevents futile SAM cycling and maintains nucleotide pools in one-carbon metabolism.

Bhatia, Muskan; Thakur, Jyotika; Suyal, Shradha; Oniel, Ruchika; Chakraborty, Rahul; Pradhan, Shalini; Sharma, Monika; Sengupta, Shantanu; Laxman, Sunil; Masakapalli, Shyam Kumar; Bachhawat, Anand Kumar

Bhatia, Muskan; Thakur, Jyotika; Suyal, Shradha; Oniel, Ruchika; Chakraborty, Rahul; Pradhan, Shalini; Sharma, Monika; Sengupta, Shantanu; Laxman, Sunil; Masakapalli, Shyam Kumar; Bachhawat, Anand Kumar.

Afiliação

Bhatia M; Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, S.A.S. Nagar, Punjab, India.
Thakur J; BioX Center, School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India.
Suyal S; Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, S.A.S. Nagar, Punjab, India.
Oniel R; Institute for Stem Cell Science and Regenerative Medicine (inStem), NCBS-TIFR Campus, Bangalore, India.
Chakraborty R; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, New Delhi, India.
Pradhan S; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, New Delhi, India.
Sharma M; Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, S.A.S. Nagar, Punjab, India.
Sengupta S; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, New Delhi, India.
Laxman S; Institute for Stem Cell Science and Regenerative Medicine (inStem), NCBS-TIFR Campus, Bangalore, India.
Masakapalli SK; BioX Center, School of Basic Sciences, Indian Institute of Technology Mandi, Kamand, Himachal Pradesh, India.
Bachhawat AK; Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, S.A.S. Nagar, Punjab, India. Electronic address: anand@iisermohali.ac.in.

J Biol Chem ; 295(47): 16037-16057, 2020 11 20.

Article em En | MEDLINE | ID: mdl-32934008

Assuntos

Trifosfato de Adenosina/química; Metilenotetra-Hidrofolato Redutase (NADPH2)/química; S-Adenosilmetionina/química; Proteínas de Saccharomyces cerevisiae/química; Saccharomyces cerevisiae/enzimologia; Trifosfato de Adenosina/genética; Trifosfato de Adenosina/metabolismo; Regulação Alostérica; Humanos; Metilação; Metilenotetra-Hidrofolato Redutase (NADPH2)/genética; Metilenotetra-Hidrofolato Redutase (NADPH2)/metabolismo; S-Adenosilmetionina/metabolismo; Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo

Palavras-chave

AMP; MTHFR; S-adenosylmethionine (SAM); Saccharomyces cerevisiae; allosteric regulation; feedback insensitive; futile cycle; methionine; nucleotide depletion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article