Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12-dimethylbenz[a]anthracene-induced hamster oral cancer via the down-regulation of PI3K/AKT/mTOR signaling pathways.

Pu, Yumei; Hu, Shiqi; Chen, Yongfeng; Zhang, Qian; Xia, Chengwan; Deng, Han; Wang, Yuxin; Hu, Qingang

Pu, Yumei; Hu, Shiqi; Chen, Yongfeng; Zhang, Qian; Xia, Chengwan; Deng, Han; Wang, Yuxin; Hu, Qingang.

Afiliação

Pu Y; Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Hu S; Department of Oral Pathology, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Chen Y; Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College, Anhui, China.
Zhang Q; Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Xia C; Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Deng H; Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Wang Y; Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Hu Q; Department of Oral and Maxillofacial Surgery, Nanjing Stomatology Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.

Environ Toxicol ; 36(3): 339-351, 2021 Mar.

Article em En | MEDLINE | ID: mdl-33068063

Assuntos

9,10-Dimetil-1,2-benzantraceno/toxicidade; Benzoquinonas/farmacologia; Álcool de Polivinil/farmacologia; 9,10-Dimetil-1,2-benzantraceno/efeitos adversos; Alginatos/efeitos adversos; Animais; Antracenos/efeitos adversos; Anticarcinógenos/farmacologia; Carcinogênese/efeitos dos fármacos; Carcinógenos; Carcinoma de Células Escamosas/patologia; Bochecha/patologia; Cricetinae; Regulação para Baixo/efeitos dos fármacos; Masculino; Mesocricetus; Neoplasias Bucais/patologia; Fosfatidilinositol 3-Quinases/metabolismo; Álcool de Polivinil/metabolismo; Álcool de Polivinil/uso terapêutico; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais/efeitos dos fármacos; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

DMBA; PI3K/AKT/mTOR; hamster; nanocarrier; oral cancer; thymoquinone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article