A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-&#954;B-mediated inflammatory responses.

Li, Li; Ding, Chunyong; Zou, Chunpeng; Xiong, Zhi; Zhu, Weiwei; Qian, Jianchang; Xu, Mingjiang; Zhang, Ao; Liang, Guang

A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-κB-mediated inflammatory responses.

Li, Li; Ding, Chunyong; Zou, Chunpeng; Xiong, Zhi; Zhu, Weiwei; Qian, Jianchang; Xu, Mingjiang; Zhang, Ao; Liang, Guang.

Afiliação

Li L; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Anesthesiology, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.
Ding C; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.
Zou C; Department of Ultrasonography, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xiong Z; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, Nanchang University, Nanchang 330031, Jiangxi, China.
Zhu W; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qian J; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Xu M; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhang A; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: ao6919zhang@sjtu.edu.cn.
Liang G; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: wzmcliangguang@163.com.

Toxicol Appl Pharmacol ; 409: 115322, 2020 12 15.

Article em En | MEDLINE | ID: mdl-33171189

Assuntos

Anti-Inflamatórios/farmacologia; Diabetes Mellitus Experimental/complicações; Nefropatias Diabéticas/tratamento farmacológico; Inflamação/tratamento farmacológico; NF-kappa B/metabolismo; Animais; Linhagem Celular; Citocinas/metabolismo; Diabetes Mellitus Experimental/metabolismo; Nefropatias Diabéticas/metabolismo; Células Epiteliais/efeitos dos fármacos; Células Epiteliais/metabolismo; Fibrose/tratamento farmacológico; Fibrose/metabolismo; Glucose/metabolismo; Inflamação/metabolismo; Túbulos Renais/efeitos dos fármacos; Túbulos Renais/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Ratos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Cytokines; Diabetic nephropathy; Fibrosis; Inflammation; Macrophage infiltration; Nuclear factor-kappa B; Salviadione derivative 15a

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article