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Treatment of primate platynosomosis: A word of caution about the use of praziquantel in marmosets.
Mati, Vitor Luís Tenório; Pinto, Hudson Alves; de Melo, Alan Lane.
Afiliação
  • Mati VLT; Departamento de Ciências da Saúde, Universidade Federal de Lavras, Lavras, Brazil.
  • Pinto HA; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • de Melo AL; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
J Med Primatol ; 50(1): 60-66, 2021 02.
Article em En | MEDLINE | ID: mdl-33186482
BACKGROUND: The successive reports of Platynosomum illiciens in Neotropical captive primates have increased interest in platynosomosis; however, its treatment is little known. METHODS: Callithrix penicillata (n = 10) naturally and chronically infected with P. illiciens were treated with praziquantel (25 mg/kg BW, three s.c. doses at 24 hours intervals), and coproparasitological tests performed over 67 days. The proportions of primates with a reduction in fecal egg counts (FEC) or negative results progressively increased after treatment, and at the last fecal tests, marmosets were negative. RESULTS AND CONCLUSIONS: Although all primates tolerated the initial days of study well, 40% (4/10) of them died between the 8th and 16th days after the onset of treatment. Clinical signs and necropsies indicated the occurrence of hepatic involvement, biliary obstruction, and cholangitis. Marmosets with a higher previous FEC were more likely to die after treatment. Use of praziquantel should be considered carefully on a case-by-case basis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2021 Tipo de documento: Article