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MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection.
Zhou, Lanlan; Huntington, Kelsey; Zhang, Shengliang; Carlsen, Lindsey; So, Eui-Young; Parker, Cassandra; Sahin, Ilyas; Safran, Howard; Kamle, Suchitra; Lee, Chang-Min; Geun Lee, Chun; A Elias, Jack; S Campbell, Kerry; T Naik, Mandar; J Atwood, Walter; Youssef, Emile; A Pachter, Jonathan; Navaraj, Arunasalam; A Seyhan, Attila; Liang, Olin; El-Deiry, Wafik S.
Afiliação
  • Zhou L; Brown Experimentalists Against COVID-19 (BEACON) Group, Brown University, Providence, RI 02912, USA.
  • Huntington K; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • Zhang S; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • Carlsen L; The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI 02912, USA.
  • So EY; Cancer Center at Brown University, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • Parker C; Warren Alpert Medical School, Brown University, Providence, RI 02912, USA
  • Sahin I; Brown Experimentalists Against COVID-19 (BEACON) Group, Brown University, Providence, RI 02912, USA.
  • Safran H; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • Kamle S; The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI 02912, USA.
  • Lee CM; Cancer Center at Brown University, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • Geun Lee C; Warren Alpert Medical School, Brown University, Providence, RI 02912, USA
  • A Elias J; Pathobiology Graduate Program, Brown University, Providence, RI 02912, USA
  • S Campbell K; Brown Experimentalists Against COVID-19 (BEACON) Group, Brown University, Providence, RI 02912, USA.
  • T Naik M; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • J Atwood W; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • Youssef E; The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI 02912, USA.
  • A Pachter J; Cancer Center at Brown University, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • Navaraj A; Warren Alpert Medical School, Brown University, Providence, RI 02912, USA
  • A Seyhan A; Brown Experimentalists Against COVID-19 (BEACON) Group, Brown University, Providence, RI 02912, USA.
  • Liang O; Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
  • El-Deiry WS; The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Providence, RI 02912, USA.
Oncotarget ; 11(46): 4201-4223, 2020 11 17.
Article em En | MEDLINE | ID: mdl-33245731
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article