Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t.

Ward, Richard J; Pediani, John D; Marsango, Sara; Jolly, Richard; Stoneman, Michael R; Biener, Gabriel; Handel, Tracy M; Raicu, Valerica; Milligan, Graeme

Ward, Richard J; Pediani, John D; Marsango, Sara; Jolly, Richard; Stoneman, Michael R; Biener, Gabriel; Handel, Tracy M; Raicu, Valerica; Milligan, Graeme.

Afiliação

Ward RJ; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
Pediani JD; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
Marsango S; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
Jolly R; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
Stoneman MR; Physics Department, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Biener G; Physics Department, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Handel TM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
Raicu V; Physics Department, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Milligan G; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom. Electronic address: Graeme.Milligan@glasgow.ac.uk.

J Biol Chem ; 296: 100139, 2021.

Article em En | MEDLINE | ID: mdl-33268380

Assuntos

Benzilaminas/farmacologia; Ciclamos/farmacologia; Receptores CXCR4/antagonistas & inibidores; Receptores CXCR4/metabolismo; Bibliotecas de Moléculas Pequenas/farmacologia; Tioureia/farmacologia; Fármacos Anti-HIV/farmacologia; Células Cultivadas; Proteínas de Fluorescência Verde/metabolismo; Compostos Heterocíclicos/química; Compostos Heterocíclicos/farmacologia; Humanos; Ligantes; Ligação Proteica; Conformação Proteica/efeitos dos fármacos; Multimerização Proteica/efeitos dos fármacos; Receptores CXCR4/química; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/isolamento & purificação; Proteínas Recombinantes de Fusão/metabolismo; Transdução de Sinais

Palavras-chave

G proteincoupled receptor (GPCR); chemokine; confocal microscopy; dimerization; microscopic imaging; oligomerization; tertiary structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article